Transcriptomic signature of Bexarotene (Rexinoid LGD1069) on mammary gland from three transgenic mouse mammary cancer models
نویسندگان
چکیده
منابع مشابه
Abnormal mammary gland development in MMTV-CBLC transgenic mouse.
The CBL family of E3 ubiquitin ligases regulates cell signaling in a number of tissues by promoting degradation of tyrosine kinase receptors such as epidermal growth factor receptor. CBLC, the third member of the CBL family, is expressed in epithelial tissues, including the mammary gland. A transgenic mouse strain expressing a tetracyclin-inducible CBLC in the mammary gland was derived. It was ...
متن کاملEvaluation of mammary gland development and function in mouse models.
The human mammary gland is composed of 15-20 lobes that secrete milk into a branching duct system opening at the nipple. Those lobes are themselves composed of a number of terminal duct lobular units made of secretory alveoli and converging ducts. In mice, a similar architecture is observed at pregnancy in which ducts and alveoli are interspersed within the connective tissue stroma. The mouse m...
متن کاملHumanization of the mouse mammary gland.
Although mouse models have provided invaluable information on the mechanisms of mammary gland development, anatomical and developmental differences between human and mice limit full understanding of this fundamental process. Humanization of the mouse mammary gland by injecting immortalized human breast stromal cells into the cleared murine mammary fat pad enables the growth and development of h...
متن کاملCancer Prevention Research Prevention of Tumorigenesis in p53-Null Mammary Epithelium by Rexinoid Bexarotene, Tyrosine Kinase Inhibitor Gefitinib, and Celecoxib
The chemopreventive effects of three agents, rexinoid bexarotene, tyrosine kinase inhibitor gefitinib, and celecoxib, were tested on mammary tumor development arising in p53-null mammary epithelium. The rexinoid bexarotene was the most efficacious inhibitor as it reduced mammary tumor development by 75% in virgin mice and significantly delayed mean tumor development by 98 days in hormone-stimul...
متن کاملMammary gland development and cancer.
The mammary gland is a complex organ that begins development early in gestation and constantly changes in size, shape and function from the time of puberty to menopause. The earliest stages of embryogenesis appear to be independent of steroid hormones, whereas after the 15th week breast structure is largely influenced by a variety of hormones. In most females, further breast development begins ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Medical Genomics
سال: 2008
ISSN: 1755-8794
DOI: 10.1186/1755-8794-1-40